May 2019 Volume LIV Number 3


Evidence-Based Dentistry Workgroup Updates

March 2016 Volume LI Number 2


The AAPD has been working concurrently on three evidence-based systematic reviews: vital pulp therapy, non-vital pulp therapy and sealants (co-sponsored by the ADA). The pulp therapy workgroup has been working on two evidence-based systematic reviews: vital pulp therapy and non-vital pulp therapy.  

Pulp Therapy Systematic Reviews

The pulp therapy workgroup (Drs. Coll, Marghalani, Seale and Vargas) met for two days at headquarters in November to review the meta-analyses of over 50 randomized controlled trials of pulp therapy. The studies have been statistically analyzed and the workgroup has produced evidence tables from their findings. The workgroup assessed the quality of evidence across studies for each important outcome using GRADE. Transparent, repeatable and explicit processes have been used to make judgments about the quality of evidence for important outcomes; clinical and radiographic success of pulp therapies are the outcomes of interest.

In March, a draft of the report will be submitted to CCA and CSA per the stated process. A final report will be presented to the Board at Annual Session and the full systematic review will be published in the 2016 September/October issue of Pediatric Dentistry. Progress is being made in the production of the non-vital pulp therapy review; protocol will be published and registered in early 2016. 

Sealant Guidelines

The sealant systematic review panel, a joint project of the ADA and AAPD, met in August to review the findings of the meta-analysis, the synthesis of data from randomized-controlled trials selected for inclusion in review. The panel is currently formulating the evidence statements. Evidence statements explain whether or not there is a benefit to using the intervention or diagnostic technique and the level of certainty in the estimate of the effect. Once these statements are finished, the review will be written. Publication is slated for spring of 2016.

1Grading of Recommendations Assessment, Development and Evaluation- working group

2GRADE Working Group. "Grading quality of evidence and strength of recommendations." BMJ: British Medical Journal 328.7454 (2004): 1490.

3ADA Clinical Practice Guidelines Handbook

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